Premig

acetylsalicylate lysine + metoclopramide

Premig is used to relieve migraine, headache, nausea, vomiting; heartburn, stomach pain bloating; and a persistent feeling of fullness after meals. It can also be prescribed for other uses; ask your doctor or pharmacist for more information.

Premig is combination of a non-steroidal anti-inflammatory drug and an anti-sickness drug. This medicine contains two active ingredients, lysine acetylsalicylate and metoclopramide. Lysine acetylsalicylate is a soluble form of acetylsalicyclic acid, otherwise known as aspirin. Aspirin is a painkiller that belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. During a migraine attack sufferers can often feel sick or vomit. Metoclopramide is used to treat the nausea (feeling sick) and vomiting (being sick) you may get with migraine attacks. Metoclopramide is an antisickness medicine (antiemetic). It works primarily by blocking dopamine receptors that are found in an area of the brain known as the chemoreceptor trigger zone (CTZ). This reduces the sensation of nausea and prevents vomiting.

Metoclopramide comes as a tablet and liquid to take by mouth. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metoclopramide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Most patients get relief from headache intensity and are free of nausea or vomiting two hours after a single administration.

For better and faster relief, take Premig as soon as first symptoms appear.

Precautions to follow:
Before taking this medicine, tell your doctor or pharmacist if you are allergic to metoclopramide or any other drugs and what prescription and nonprescription medications you are taking. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking metoclopramide.

Tell your doctor if you have or have ever had an adrenal tumor; a seizure disorder; Parkinson's disease; high blood pressure; heart, liver, or kidney disease; a history of mental illness or depression; or an intestinal blockage or bleeding. Also consult with your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.

You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you and remember that alcohol can add to the drowsiness caused by this drug.

Side effects:
Although side effects from metoclopramide are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away: drowsiness, restlessness, fatigue, constipation, diarrhea.

If you experience any of the following symptoms, call your doctor immediately: involuntary movements of the limbs or eyes; spasm of the neck, face, and jaw muscles; change in mood (depression).

Effective dosage:
3 sachets/day

Drug Class: Head ache.